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KMID : 0894520120160030155
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Development & Reproduction
2012 Volume.16 No. 3 p.155 ~ p.168
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The Suicide Gene Diphtheria Toxin A Based Therapy in Cancer Treatment
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Anh Nguyen.T.Q
Jeong Dong-Kee
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Abstract
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Therapeutic cancer is a long lasting and turbulent history accompany with the milestones in surgical intervention, chemotherapy and radiotherapy. In the past decade, however, metastatic cancer still obstinately exists challenging the professional scientist. Beside the major forms of cancer treatment, Diphtheria toxin (DT) which is produced by a pathogenic strain of bacterium Corynebacterium diphtheria to shield themselves against the other dangerous organism, have been researched as a potential candidate to overcome the drawback such as non-specific, non-effect to drug resistant cancer cell and side effects when using chemotherapy and radiotherapy. In the context of suicide gene therapy, the DT expression under controlling of tissue-specific promoter will be targeted in cancer cell but defect in normal cell. The molecular mechanism, characteristic of DT-bases therapy and prominent achievements of preclinical and clinical studies for the past decade are summarized and discussed in this review.
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KEYWORD
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Diphtheria toxin A, Suicide gene, Tissue-specific promoter, Gene delivery
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